Lambda-Display: A Powerful Tool for Antigen Discovery

Predictive methods as a powerful tool in drug discovery

A development of a new drug is an extremely complex process, with average costs over $900 million and a time span up to 15 years. Regulatory hurdles are progressively higher, costs are escalating and the competition is ever tougher. All these factors drive pharmaceutical companies to shorten the Research & Development (R&D) process as much as possible. Consequently, methodologies for increasing...

Habitat Simulation Technique as a Powerful Tool for Instream Flow Needs Assessment and River Ecosystem Management

Instream flow needs (IFN) assessment studies are performed to provide guidelines for stream water management and to assess the impacts of different water projects such as weirs, dams and stream diversions on the available fish habitat. The physical habitat simulation is one of the IFN assessment methods and also a powerful tool in management of river ecosystem that has not become a common metho...

Investigation of a Powerful Tool for the Development of Thinly Bedded Carbonate Reservoirs (TECHNICAL NOTE)

In thin-layered reservoirs, drilling engineers face tough challenges—planning their drilling programs to follow the most productive reservoir layers while avoiding nearby water, gas or high-pressure zones. The rewards for a successful drilling strategy are clear—increased oil production and reduced water cut. In an oil field in the Persian Gulf, for example, oil production was increased four- t...

Application of Genetic Programming as a Powerful Tool for Modeling of Cellulose Acetate Membrane Preparation

Discovery of Novel Peptidomimetics for Brain-Derived Neurotrophic Factor using Phage Display Technology

Brain-Derived Neurotrophic Factor (BDNF) is a neuroprotectant candidate for neurodegenerative diseases. However, there are several clinical concerns about its therapeutic applications. In the current study, we selected BDNF-mimicking small peptides from phage-displayed peptide library as alternative molecules to the clinical challenges. The peptide library was screened against BDNF receptor (Ne...